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KMID : 0043319870100030165
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Archives of Pharmacal Research
1987 Volume.10 No. 3 p.165 ~ p.168
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Effect of Scoparone on the Hepatic Microsomal UDPglucuronyltransferase Activity in Mice
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Huh K
Lee SI/Park JM
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Abstract
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The effect of scoparone on UDPglucuronyltransferase in mouse hepatic microsomes was studied. After treatment with scoparone, hepatic microsomal UDPglucuronyltransferase activity was increased with dose-dependent manner as compared to control. The Vmax value (control=23.2nmoles/mg protein/min, scoparone=31.2nmoles/mg protein/min) without affecting the Km value (414mcM) for p-nitrophenol was increased by the scoparone treatment, and the pattern of kinetic studies for UDP-glucuronic acid was also similar to those of p-nitrophenol. Whereas, the hepatic microsomal UDPglucuronyltransferase was not changed by the addition of scoparone in vitro. The results obtained suggest that the characteristics of increase in the enzyme activity may include induction of enzyme proteins.
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KEYWORD
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